Researchers identify signaling molecule that may help prevent Alzheimers disease

New research in humans and mice identifies a particular signaling molecule that can help modify inflammation and the immune system to protect against Alzheimer’s disease. The work, which was led by investigators at Massachusetts General Hospital (MGH), is published in Nature. Cognitive decline associated with Alzheimer’s disease develops when neurons begin to die. “Neuron death […]

Poor survival after heart attack linked to excess levels of signaling protein in heart

About 6.2 million Americans suffer from heart failure, an incurable disease with a staggering mortality rate—some 40 percent of patients die within five years of diagnosis. Heart failure is one form of heart disease for which new therapies are desperately needed. Now, in new work, scientists at the Lewis Katz School of Medicine (LKSOM) at […]

Scientists leverage interference between signaling pathways for cancer treatment

In order for cancer to form in the human body, normal cells must acquire multiple mutations before they develop toward the disease. It was previously believed that these mutations acted in concert in the progression of cancer. But a new Nature study led by City of Hope’s Markus Müschen, M.D., Ph.D., chair of the Department […]

Manipulating cell death signaling after radiation could offer a new way to treat cancers

Cancer cells avoid an immune system attack after radiation by commandeering a cell signaling pathway that helps dying cells avoid triggering an immune response, a new study led by UTSW scientists suggests. The findings, published in a recent issue of Nature Immunology, could eventually lead to new ways to augment existing treatments to fight this […]