Researchers have long sought to explain precisely how the most common genetic mutation linked to both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia causes the death of nerve cells. Now, Johns Hopkins Medicine researchers report new evidence that the mutation slowly disrupts the vital transport system of proteins, enzymes and other material in and out […]
Scientists at the University Bath have discovered a series of protein structures that are thought to be highly relevant to the onset of Parkinson’s disease. It is hoped that further analysis of these structures will open up a new avenue for potential treatment for a disease that is the fastest growing neurological condition in the […]
More effective measures to prevent infection spreading within households are a vital part of preventing a second wave of COVID-19, say researchers at the Universities of Birmingham and Warwick. In an article published in the BMJ, experts at the University of Birmingham’s Institute of Applied Health Research and Warwick Medical School argue that robust strategies […]
Head and neck cancer is one of the leading causes of cancer-related deaths worldwide, and squamous cell carcinomas (HNSCC) account for the majority of these cases. In a new study, based on preclinical research and published July 29, 2020 in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, researchers at University […]
Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Instituto de Investigación Sanitaria Princesa (IIS Princesa) have made a major advance toward deciphering the mechanism through which the production of reactive oxygen species (ROS) increases in the early phases of hypoxia (acute reduction in tissue oxygen). The finding represents an important advance in […]
A team led by scientists at Scripps Research has discovered a common molecular feature found in many of the human antibodies that neutralize SARS-CoV-2, the coronavirus that causes COVID-19. The scientists, whose study appears July 13 in Science, reviewed data on nearly 300 anti-SARS-CoV-2 antibodies that their labs and others have found in convalescent COVID-19 […]
Sudden school closures in the United States were undertaken to reduce COVID-19 transmission this spring. Those closures were not typical, and how and when schools reopen will create a set of new norms, with unique stressors for students, families, school personnel, and communities. The challenges of reopening are not easy, and there will be a […]
The 1889 outbreak of influenza was first reported in the Russian city of Petropavlovsk in September of that year. Within a few weeks it had spread throughout Russia, and by early November it had appeared in most European capital cities. In mid-November it appeared in the UK, spreading rapidly in London and other large towns […]
A new type of test that uses complex sugars to detect prostate cancer earlier and with greater accuracy is being developed by researchers at the University of Birmingham. The test works by identifying sugars, known as glycans, in blood. These sugars are attached to protein molecules called PSA and are known to undergo distinct but […]
How hepatitis A virus (HAV) manages to enter liver cells called hepatocytes and initiate infection had remained a mystery for fifty years until now. University of North Carolina School of Medicine researchers designed experiments using gene-editing tools to discover how molecules called gangliosides serve as de facto gatekeepers to allow the virus entry into liver […]
