More evidence is urgently needed on opioid use in Black communities

Although the prevalence of opioid use among Black people is comparatively low, the rate of opioid deaths has increased the sharpest and fastest among that population in recent years, according to an article in the March/April issue of Harvard Review of Psychiatry. The review by Ayana Jordan, MD, Ph.D., of Yale University School of Medicine […]

Immune cells in cerebrospinal fluid predict response to immunotherapy

Results from a study led by Joan Seoane, Director of Preclinical and Translational Research co-program at VHIO and ICREA Professor, show that immune cells accessing cerebrospinal fluid faithfully recapitulate the characteristics of cells identified in brain metastasis, and could therefore constitute novel biomarkers of response to immune-based therapies. Immune checkpoint inhibitors including anti-PD1, anti-PD-L1, and […]

Huntington’s disease driven by slowed protein-building machinery in cells

In 1993, scientists discovered that a single mutated gene, HTT, caused Huntington’s disease, raising high hopes for a quick cure. Yet today, there’s still no approved treatment. One difficulty has been a limited understanding of how the mutant huntingtin protein sets off brain cell death, says neuroscientist Srinivasa Subramaniam, Ph.D., of Scripps Research, Florida. In […]

CVD risk factors tied to cognitive impairment in schizophrenia

(HealthDay)—Cardiovascular risk factors are associated with cognitive impairment among individuals with schizophrenia, according to a review and meta-analysis published online March 3 in JAMA Psychiatry. Katsuhiko Hagi, Ph.D., from Sumitomo Dainippon Pharma in Tokyo, and colleagues conducted a systematic review and meta-analysis to examine the association between risk factors for cardiovascular disease (CVD) and cognition […]

Study reveals impact of lockdown on violence in a UK capital city

The first UK COVID-19 lockdown saw a “rapid and sustained” fall in violence outside the home in the Welsh capital city, a new study led by Cardiff University has shown. Researchers from Cardiff University’s Crime and Security Research Institute (CSRI) and the US Centers for Disease Control and Prevention studied data from Cardiff’s sole emergency […]

States Aim to Chip Away at Abortion Rights With Supreme Court in Mind

When Rep. Lola Sheldon-Galloway introduced a bill in the Montana House two years ago that would have prohibited abortions after 20 weeks of pregnancy, the Republican legislator knew it was unlikely to survive the veto pen of the Democratic governor. Sure enough, then-Gov. Steve Bullock vetoed that bill and two other anti-abortion measures passed by […]