A new study, released on the bioRxiv* preprint server, shows that rapamycin, an immunosuppressive drug used in some cancers, and its analogs, may have an undesirable effect on viral entry into the host cells. This finding could inform their use to treat symptomatic coronavirus disease 2019 (COVID-19). There is a serious lack of effective antivirals […]
The lack of new or repurposed drugs to treat patients with severe or critical coronavirus disease 2019 (COVID-19) has been one of the biggest hurdles to reducing mortality rates in the ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A new study, published online in the journal Drug Development Research, describes […]
The rollout of vaccines is on in an attempt to achieve population immunity against the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the recent emergence of several variants that have altered transmissibility, infectivity and virulence characteristics has cast doubt on the feasibility of this goal. A […]
A new study published in the journal Science Immunology analyzed lung epithelial cells from patients infected with COVID-19 and found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces the complement system as a dangerous weapon for viral infection. The complement system is an extension of the innate immune system to recognize pathogens and remove […]
For the millions of people worldwide who have sickle cell disease, there are only a few treatment options, which include risky bone marrow transplants, gene therapy or other treatments that address a subset of symptoms. Today, researchers will describe the discovery of a small molecule with the potential to address the root cause of sickle […]
A team led by a biomedical scientist at the University of California, Riverside, has developed a new RNA-sequencing method– "Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing," or PANDORA-seq — that can help discover numerous modified small RNAs that were previously undetectable. RNA plays a central role in decoding the genetic information in DNA […]
Cell Migration Assays from Platypus Technologies utilize exclusion-zone technology, ensuring that results are high quality and ideal for publication. Researchers in both pharmaceutical companies and academia will benefit from the use of robust, powerful Cell Migration Assays by Platypus Technologies, particularly in studies looking to advance cancer research, drug discovery, or wound healing. Cell Migration […]
New research led by investigators at Massachusetts General Hospital (MGH) provides insights on why people with red hair exhibit altered sensitivity to certain kinds of pain. The findings are published in Science Advances. In people with red hair (as in numerous other species of animals with red fur), the pigment-producing cells of the skin–called melanocytes–contain […]
Type I diabetes mellitus (T1D) is an autoimmune disorder leading to permanent loss of insulin-producing beta-cells in the pancreas. In a new study, researchers from the University of Tokyo developed a novel device for the long-term transplantation of iPSC-derived human pancreatic beta-cells. T1D develops when autoimmune antibodies destroy pancreatic beta-cells that are responsible for the […]
Researchers have succeeded in revealing the arsenal used by protozoans of the genus Leishmania in human cells to make leishmaniasis more severe, especially in cases of the mucocutaneous variety of the disease, which can cause deformations in patients. The discovery points the way to a search for novel treatments for the disease as well as […]
