RNA editing protein ADAR1 protects telomeres and supports proliferation in cancer cells

Scientists at The Wistar Institute identified a new function of ADAR1, a protein responsible for RNA editing, discovering that the ADAR1p110 isoform regulates genome stability at chromosome ends and is required for continued proliferation of cancer cells. These findings, reported in Nature Communications, reveal an additional oncogenic function of ADAR1 and reaffirm its potential as […]

Novartis’s Bid to Repurpose Inflammation Drug Ilaris Takes Another Hit

ZURICH (Reuters) – Novartis’s uphill struggle to re-purpose its inflammation drug Ilaris took another hit when the Swiss drugmaker said on Tuesday that the medicine failed to boost overall survival in lung cancer patients in a late-stage trial. The drug, known generically as canakinumab and long approved to treat juvenile arthritis and rare Mediterranean fever, […]

Researchers establish organoid culture models from prostate tumor biopsies

Scientists at Urology Research Laboratory of the Department for BioMedical Research (DBMR), University of Bern and Urology Department of the Inselspital of Bern, have established organoid culture models from prostate tumor biopsies. These are small clusters of cells which can be used to test the efficacy of various drugs. In this way, it is possible […]

Genetic Testing for Breast and Ovarian Cancer

A large, retrospective study shows how germline genetic testing has evolved over time in women with breast or ovarian cancer and reveals a path forward for testing these patients. Investigators found racial and ethnic disparities in genetic testing as well as “persistent underuse” of testing in patients with ovarian cancer. The team also discovered that […]

Walking pace among cancer survivors may be important for survival

A new study led by Washington University School of Medicine in St. Louis and the National Cancer Institute (NCI) has identified an association between slow walking pace and an increased risk of death among cancer survivors. While the study does not establish that slow walking is a cause of death, the association persisted across at […]

Why Nigeria must include parents in plans to protect girls from cervical cancer

Cervical cancer is the second most common cancer among women in Nigeria. There were 31,955 new cervical cancer cases in West Africa in 2018, and Nigeria accounted for almost half (14,943). There were also 10,403 deaths (28 deaths every day) from cervical cancer in the country in the same year. About 70% of all cervical […]

Covid jab may help fight cancer, chronic pain… and even Alzheimer's

The coronavirus jab’s most tantalising side effects? It may help fight cancer, chronic pain… and even Alzheimer’s Scientists have documented the unexpected benefits of vaccines for decades Some experts suggest vaccines can ‘train’ the immune system, strengthening it Others say increased stress hormones affect cells’ ability to target infections Joan Wakefield has barely been able to walk […]