Charité-study: Severity of SARS-CoV-2 infection on blood picture

The blood picture of COVID-19-Affected, which are slightly ill, differs according to a recent German study of the blood of seriously ill persons. The blood Profiles could help doctors in the future, the decision about the type of treatment.

Researchers from the Charité – Universitätsmedizin Berlin, and the Francis Crick Institute have in the blood of COVID-19-Ill 27 proteins identified, which allow a prediction of disease progression. The results of the research were recently presented in the prestigious scientific journal “Cell system”.

COVID-19 has different faces

In the course of a COVID-19-disease can vary from person to person very differently. While some people do not notice a SARS-CoV-2-Infekion even, develop progressions, the most people only mild disease. In some patients, severe to life-threatening disease, make intensive medical treatment is required.

Severity of the disease with biomarkers to determine

Currently there is a lack of reliable forecasts to the progression of the disease to assess. The researchers were therefore looking for biological characteristics, so-called biomarkers, which allow you to say such a in advance. With the latest methods of analysis allowed the research team the largest known number of biomarkers in the blood plasma of COVID to detect 19 patients and patients related to the Severity of the disease.

Proteins could predict the progression of the disease, for sure

The Team analyzed the blood plasma of 31 COVID-19-Patients with varying degrees of symptoms. This identified 27 proteins were then tested on a group of 17 COVID-19-Affected and 15 healthy Participants. In all cases, the signature of the proteins agreed with the actual course of the disease.

“These results lay the Basis for two types of application possibilities,” says research leader Professor Dr. Markus Ralser. The method for the prediction of the COVID-19-disease prognosis could be used. “On the other hand, the use of our technology is as a diagnostic Test in the hospital is clarity about the patient’s condition, regardless of how the Sick, self-Constitution describes how,” says Ralser.

Decision-making facilitation

This enables the attending Physicians to estimate whether an individual will develop open severe symptoms or not, wourch lives can be saved, as earlier identified, which Patients will need intensive medical care.

COVID-19-people often underestimate their condition incorrectly

At COVID-19-disease is a well-known Problem that in many cases, react too late, because the Affected to assess their health status incorrectly. “Under the circumstances, the patient’s symptoms seem better, as his state of health is really as a objective assessment via biomarkers can be profile very valuable,” emphasizes the head of research. The study team will review the procedure to a larger number of patients, in order to Refine the diagnostic Test. (vb)

Also read: Coronavirus spread: nose COVID-19-course of a disease.

Authors and source of information

This Text meets the requirements of the medical literature, medical guidelines, as well as current studies and was examined by doctors and Medical scientists.