Stop-signal task may aid assessment of adult ADHD

The stop-signal task may be valuable for assessing inhibitory control deficits in adult attention-deficit/hyperactivity disorder (ADHD), according to a systematic review and meta-analysis published online June 10 in Neuropsychology Review. Daniel Senkowski, Ph.D., from Charité-Universitätsmedizin Berlin, and colleagues conducted a systematic literature review to understand neurocognitive deficits underlying adult ADHD. Analysis included 26 publications examining […]

Researchers identify potential target in myeloid malignancies

Researchers at Children’s Hospital of Philadelphia (CHOP) have identified a molecule that plays a role in post-translational modification and activation in myeloid malignancies, making it a potential therapeutic target. The findings were published today in the Journal of Clinical Investigation. A group of proteins known as RAS proteins control signaling pathways that regulate several important […]

Tracing the evolutionary origin of cognitive flexibility

Cognitive flexibility is essential for the survival of all species on Earth. It is particularly based on functions of the orbitofrontal cortex located in the frontal brain. “The loss of cognitive flexibility in everyday life is a key factor in many neuropsychiatric diseases,” state Professor Burkhard Pleger and first author Dr. Bin Wang from the […]

Impaired histone inheritance accelerates breast cancer growth and metastasis, study shows

Chromatin states and their associated epigenetic information play a crucial role in maintaining the identity of cells as they divide. Histone post-translational modifications (PTMs) are important determinants of the cellular epigenetic state, carrying epigenetic information and regulating gene transcription. Epigenetic aberrations are linked to various diseases, including cancer. However, the role of parental histone inheritance […]

Mum, 33, dies from incurable cancer after seeing GP with really bad cough

Zoe Winters explains how to check for breast cancer Kirsty Guy, 33, had previously successfully battled breast cancer back when she was pregnant with her daughter Hallie. Following an ordeal of difficult treatment and having her baby prematurely, the brave mum-of-two was eventually given the all-clear from the deadly disease. However, two years later, something […]

Eating dark chocolate could protect the brain from stroke, says doctor

Advert warns to act FAST when you see signs of a stroke A stroke is a serious and potentially fatal medical emergency that occurs when blood flow to the brain is cut off. In most cases this is caused by a blood clot, however, it can also be due to a blood vessel bursting. There […]