Lonza to up Moderna Covid jab output with Dutch production line

Swiss firm Lonza said Wednesday it will open a new production line for the drug substance in Moderna’s COVID-19 vaccine, making it possible to churn out hundreds of millions more jabs per year. The new line will be set up at Lonza’s site in Geleen, Netherlands, and is expected to begin production by the end […]

Larger sample sizes needed to avoid false negative findings in vitamin D trials

Researchers from Trinity College Dublin have developed a novel set of tools for designing vitamin D clinical trials that capture large seasonal and population-wide differences in vitamin D status, typically seen in individuals. Their study published in the journal Scientific Reports (today, Monday 31st May 2021) provides a framework for clinical trials to establish whether […]

More transparency needed to ensure success of global COVID-19 response

A lack of transparency in COVID-19 vaccine trials and deals signed between governments and drug companies could undermine the global response to the pandemic, warn researchers at the University of Toronto and Transparency International in a new report. Published by Transparency International, “For Whose Benefit?” takes an in-depth look at the development and sale of […]

Seeking a pill to cure Covid: drugmakers eye alternative to vaccines

Prevention is better than cure—but when it comes to Covid, what happens when people can’t get the vaccine, don’t want it, or they’re immune suppressed and it fails to stop infection? The hunt is on for a coronavirus treatment that can be taken as a pill soon after a confirmed positive, halting the disease in […]

How CD4+ T cells respond to SARS-CoV-2 in COVID-19 recovered patients

An international team of researchers from the Institute for Research in Biomedicine, affiliated to the Università della Svizzera italiana, has deciphered the T cell responses occurring during COVID-19 infection at single-cell resolution. This study, which was performed at the Center of Medical Immunology under the leadership of Prof. Federica Sallusto, included collaborations with clinical institutions […]

EU watchdog to rule Friday on Pfizer for youths

The European Medicines Agency will announce on Friday whether it has approved the Pfizer/BioNTech coronavirus jab for 12- to 15-year-olds, the regulator said. If approved it will be the first vaccine to get the green light for young people in the 27-nation European Union. Pfizer is currently authorised for people aged 16 and older. The […]

Chemical changes to peptide siRNA-carrier enhance gene silencing for future cancer drugs

MUSC Hollings Cancer Center researchers are exploring the use of peptide carriers for the delivery of small RNA drugs as a novel treatment for cancer. The team’s recent work, published online March 19 in the Molecular Therapy—Nucleic Acids journal, lays the foundation for developing a clinically relevant peptide carrier RNAi-based drug treatment strategy for human […]

Science moves closer to diet that improves metabolic health without sharp cuts in calories

A diet that improves the biomarkers of metabolic health, and that could potentially slow the aging process, has moved a step closer to reality. “We’ve known for years that restricting the amino acid methionine in the diet produces immediate and lasting improvements in nearly every biomarker of metabolic health,” said Thomas W. Gettys, Ph.D., Professor […]

Expert discusses how to prevent another pandemic

Michael Mina is assistant professor of epidemiology at the Harvard T.H. Chan School of Public Health, a member of the School’s Center for Communicable Disease Dynamics, and associate medical director in clinical microbiology at Brigham and Women’s Hospital’s Pathology Department. Mina’s work revolves around disease testing and the development of new technologies to better understand […]

Scientists accelerate path to drugs for COVID-19

Scientists at The University of Manchester have developed a more efficient method to produce medicines that are in development for the treatment of COVID-19, cancer and other diseases that affect many of the world’s population. New research published today, in Nature, describes a new family of enzymes (ligases) which can assemble the key chemical building […]