Scientists have successfully treated flies displaying behavioral problems linked to newly discovered schizophrenia-associated genes in humans, using common anti-psychotics. Schizophrenia is a severe long-term mental health condition that is historically poorly understood and treated. It is relatively common, affecting one to two per cent of the population, and is known to be up to 80 […]
Hallucinations in the General Population Tied to Psychiatric Disorders
Hallucinations in the general population are significantly linked to mental health disorders, suicidal ideation, and suicide attempts across the lifespan, new research shows. An analysis of a large survey of more than 33,000 participants showed that although the prevalence of hallucinations decreased markedly with age, individuals who reported hallucinations were at least twice as likely […]
CVD risk factors tied to cognitive impairment in schizophrenia
(HealthDay)—Cardiovascular risk factors are associated with cognitive impairment among individuals with schizophrenia, according to a review and meta-analysis published online March 3 in JAMA Psychiatry. Katsuhiko Hagi, Ph.D., from Sumitomo Dainippon Pharma in Tokyo, and colleagues conducted a systematic review and meta-analysis to examine the association between risk factors for cardiovascular disease (CVD) and cognition […]
‘Landmark’ Schizophrenia Drug in the Wings?
A novel therapy that combines a muscarinic receptor agonist with an anticholinergic agent is associated with a greater reduction in psychosis symptoms compared with placebo, new research shows. In a randomized phase 2 trial comprised of nearly 200 participants, xanomeline-trospium (KarXT) was generally well tolerated and had none of the common side effects linked to […]
Maturation of 'mini brain' organoids matches human brain development
A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived 'mini brain' organoids can mature in a manner that is strikingly similar to human brain development. For the new study, published in Nature Neuroscience February 22, senior authors Dr. Daniel Geschwind of UCLA and Dr. Sergiu Pasca of Stanford University […]
People with delusions understand metaphor differently – here’s how it could help explain schizophrenia
Figurative language, by which the speaker intends to communicate something other than what is actually said by the words used, is commonplace in human communication. Some claim that metaphorical expressions such as “My home has become a prison” or “My daughter is a monster” are used on average six times during every minute of conversation. […]
New way to analyze fMRI data offers path to improving treatment for schizophrenia
Researchers at the University of Maryland, Baltimore County (UMBC) have developed tools to improve the analysis of functional magnetic resonance imaging (fMRI) data. Tülay Adali, professor of computer science and electrical engineering and director of UMBC’s Machine Learning for Signal Processing Lab, and Qunfang Long, a Ph.D. candidate at UMBC in electrical engineering, have spearheaded […]