Study shows how proteins work in concert to resolve DNA double-strand breaks

From cancer treatment to sunlight, radiation and toxins can severely damage DNA in both harmful and healthy cells. While the body has evolved to efficiently treat and restore damaged cells, the mechanisms that allow this natural repair remain misunderstood. In a new study, Northwestern University researchers have used cryogenic electron microscopy (cryo-EM) to visualize this […]

Obese or overweight patients at high risk for having worse COVID-19 outcomes

Patients who are overweight or obese have more severe COVID-19 and are highly likely to require invasive respiratory support, according to a new international study. The research, led by the Murdoch Children's Research Institute (MCRI) and The University of Queensland and published in Diabetes Care, found obese or overweight patients are at high risk for […]

New grants could help protect the environment and create new therapy for Parkinson's

New grants from the State University of New York could help researchers at Binghamton University create a new therapy to provide relief to Parkinson’s patients and help locate abandoned oil and gas wells. Binghamton University researchers Christopher Bishop and Timothy de Smet have each received grants from the SUNY Technology Accelerator Fund, which helps faculty […]

COVID19's cytokine storm ushers in a local complement storm in the lungs

A new study published in the journal Science Immunology analyzed lung epithelial cells from patients infected with COVID-19 and found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces the complement system as a dangerous weapon for viral infection. The complement system is an extension of the innate immune system to recognize pathogens and remove […]

Powerful algorithms can 'predict' the biological language of cancer and Alzheimer's

Powerful algorithms used by Netflix, Amazon and Facebook can 'predict' the biological language of cancer and neurodegenerative diseases like Alzheimer's, scientists have found. Big data produced during decades of research was fed into a computer language model to see if artificial intelligence can make more advanced discoveries than humans. Academics based at St John's College, […]

Experts call for accelerated research to address concurrent HIV and COVID-19 pandemics

The COVID-19 pandemic is affecting people with or at risk for HIV both indirectly, by interfering with HIV treatment and prevention services, and directly, by threatening individual health. An effective response to these dual pandemics requires unprecedented collaboration to accelerate basic and clinical research, as well as implementation science to expeditiously introduce evidence-based strategies into […]