NEW YORK (Reuters Health) – A subset of macrophages, PTGER4+ (EP4+), are the major drivers of epithelial regeneration after intestinal inflammation and are potential targets for inflammatory bowel disease (IBD) therapy, researchers say. “Dysfunctional resolution of intestinal inflammation and altered mucosal healing are essential features in the pathogenesis of IBD,” Dr. Gianluca Matteoli of KU […]
NEW YORK (Reuters Health) – Researchers have identified the process by which adherent-invasive Escherichia coli (AIEC) bacteria drive inflammation in Crohn’s disease. They found that AIEC, which colonize the intestinal mucosa by adhering to and invading intestinal epithelial cells, can produced a metabolite that interacts with the intestine’s immune cells to induce inflammation. “Our study […]
