Researchers find a protein involved in Huntington’s disease motor deficits

Huntington’s disease is caused by a mutation in the Huntingtin gen. Patients show involuntary movements, cognitive deficits and specific psychiatric disorders resulting from the degeneration and death of medium spiny striatal neurons. A study led by researchers of the Institute of Neurosciences of the UB (UBNeuro) describes the toxic role of the protein RTP801 in […]

Unique protein structures could hold the key to Parkinson’s disease

Scientists at the University Bath have discovered a series of protein structures that are thought to be highly relevant to the onset of Parkinson’s disease. It is hoped that further analysis of these structures will open up a new avenue for potential treatment for a disease that is the fastest growing neurological condition in the […]

No NELL2, no sperm motility—novel protein is essential for male fertility

Newly produced spermatozoa within the testis are not fully functional until they mature in the epididymis, a duct that helps to transport and store sperm. Male infertility may arise from lack of communication between the testis and the epididymis and new research has uncovered a mechanism of this communication. Dr. Martin Matzuk at Baylor College […]

New method reveals how the Parkinson’s disease protein damages cell membranes

Sufferers of Parkinson’s disease have clumps of α-synuclein (alpha-synuclein), sometimes known as the “Parkinson’s protein,” found in the brain. These destroy cell membranes, eventually resulting in cell death. Now, a method developed at Chalmers University of Technology, Sweden, reveals how the composition of cell membranes seems to be a decisive factor for how small quantities […]

Mouse study shows ‘chaperone protein’ protects against autoimmune diseases

Like a parent of teenagers at a party, Mother Nature depends on chaperones to keep one of her charges, the immune system, in line so that it doesn’t mistakenly attack normal cells, tissues and organs in our bodies. A recent study by Johns Hopkins Medicine researchers has demonstrated that in mice—and probably humans as well—one […]

Protein interactions and brain function

Forty years since its discovery, much remains to be discovered about an enzyme called CaMKII that plays a key role in shaping learning and memory in the brain. Now Roger Colbran, Ph.D., graduate student Tyler Perfitt and colleagues report in the Journal of Neuroscience the discovery of a novel interaction between CaMKII and a protein […]