Fast-tracking drug development for neurodegenerative disorders

A Griffith University-led research team has discovered how a therapeutic target common among debilitating neurodegenerative disorders is activated, which could help accelerate drug development. In a study published in the journal Neuron, the researchers from Griffith University’s Institute for Glycomics, the University of Queensland and Washington University, analyzed the structure and function of a protein […]

Dormant threat: Abnormal proteins unleash latent toxicity in neurodegenerative diseases

Though neurodegenerative diseases are becoming more common in today’s aging societies, the exact way in which accumulated abnormal proteins become toxic to neurons is unknown. In a recent study conducted at Daegu Gyeongbuk Institute of Science and Technology, Korea, scientists have discovered a new mechanism of action by which these abnormal proteins actually unlock the […]

Inhibition of sphingolipid metabolism and neurodegenerative diseases

Disrupting the production of a class of lipids known as sphingolipids in neurons improved symptoms of neurodegeneration and increased survival in a mouse model, according to new research led by the joint laboratory of Robert Farese, Jr. and Tobias Walther at Harvard T.H. Chan School of Public Health and Howard Hughes Medical Institute. The findings, […]