Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Death from COVID-19 was not more likely among patients with inflammatory bowel disease (IBD) who had COVID-19 who developed new GI symptoms after becoming infected, according to international registry data from nearly 3,000 adults. Dr Ryan C. Ungaro Although GI symptoms […]
Patients treated with infliximab for inflammatory bowel disease (IBD) showed significantly reduced response to COVID-19 antibodies, compared with those treated with vedolizumab, according to data from nearly 7,000 patients. Although anti-tumor necrosis factor (anti-TNF) drugs are routinely used for patients with IBD, the impact of their immune-suppressing properties on protective immunity to COVID-19 is unknown, […]
NEW YORK (Reuters Health) – A subset of macrophages, PTGER4+ (EP4+), are the major drivers of epithelial regeneration after intestinal inflammation and are potential targets for inflammatory bowel disease (IBD) therapy, researchers say. “Dysfunctional resolution of intestinal inflammation and altered mucosal healing are essential features in the pathogenesis of IBD,” Dr. Gianluca Matteoli of KU […]
NEW YORK (Reuters Health) – Researchers have identified the process by which adherent-invasive Escherichia coli (AIEC) bacteria drive inflammation in Crohn’s disease. They found that AIEC, which colonize the intestinal mucosa by adhering to and invading intestinal epithelial cells, can produced a metabolite that interacts with the intestine’s immune cells to induce inflammation. “Our study […]
