In 1993, scientists discovered that a single mutated gene, HTT, caused Huntington’s disease, raising high hopes for a quick cure. Yet today, there’s still no approved treatment. One difficulty has been a limited understanding of how the mutant huntingtin protein sets off brain cell death, says neuroscientist Srinivasa Subramaniam, Ph.D., of Scripps Research, Florida. In […]
Huntington’s disease is caused by a mutation in the Huntingtin gen. Patients show involuntary movements, cognitive deficits and specific psychiatric disorders resulting from the degeneration and death of medium spiny striatal neurons. A study led by researchers of the Institute of Neurosciences of the UB (UBNeuro) describes the toxic role of the protein RTP801 in […]
