The inhalation of carbon dioxide (CO2) by mice a few hours after they formed a new fearful memory makes that memory stronger, so that the mice show more distress when they are prompted to 'retrieve' (ie, recall) it. That is the conclusion of a recent in Frontiers in Behavioral Neuroscience by neuroscientists from the University […]
Scientists at Cincinnati Children's appear to have flipped another piece in the underexplored puzzle of male infertility. In findings published Oct. 26, 2021, in Cell Reports, a team led by co-first authors Anna Heinrich, BS, Bidur Bhandary, PhD, and senior author Tony De Falco, PhD, sheds new light on how sperm production can go wrong […]
After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson’s disease (PD) are now actively being explored. In this special supplement to the Journal of Parkinson’s Disease, “Repairing the Parkinsonian Brain,” experts highlight some of the current strategies being pursued to restore lost function and replace what is lost in the PD brain, […]
After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson's disease (PD) are now actively being explored. In this special supplement to the Journal of Parkinson's Disease on "Repairing the Parkinsonian Brain," experts highlight some of the current strategies being pursued to restore lost function and replace what is lost in the PD […]
New information from a study reported on in STEM CELLS might result in more effective treatments for osteoarthritis and other cartilage diseases, as well as hereditary disorders affecting cartilage development. Their findings might also point to a new way to accelerate stem cell differentiation for bioengineering cartilage, the researchers say. The team, from Cytex Therapeutics […]
A first-in-kind kidney cancer drug developed from laboratory and translational studies conducted at UT Southwestern Medical Center received approval from the Food and Drug Administration, providing a new treatment for patients with familial kidney cancer. Merck's belzutifan grew out of the discovery at UT Southwestern of a protein, HIF-2α, that is key to fuel the […]
A gene called Npas4, already known to play a key role in balancing excitatory and inhibitory inputs in brain cells, appears to also be a master timekeeper for the brain’s circadian clock, new research led by UT Southwestern scientists suggests. The finding, published online today in Neuron, broadens understanding of the circadian clock’s molecular mechanisms, […]
A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH’s National Eye Institute. The findings suggest a way forward for developing neuroprotective therapies for glaucoma, a leading cause of visual impairment and blindness. The report was published in Cell. Glaucoma results from […]
In a new study on mice, Johns Hopkins Medicine researchers report that using MRI scans to measure blood volume in the brain can serve as a noninvasive way to potentially track the progress of gene editing therapies for early-stage Huntington’s disease, a neurodegenerative disorder that attacks brain cells. The researchers say that by identifying and […]
ERS Genomics Limited, which was formed to provide broad access to the foundational CRISPR/Cas9 intellectual property co-owned by Dr. Emmanuelle Charpentier, and Nippon Gene Co., Ltd (Nippon Gene), a manufacturer of genetic engineering research reagents and diagnostic reagents for humans, animals, and plants, today announced a non-exclusive license agreement granting Nippon Gene access to ERS […]
