When a new drug is being developed, the first question is, “Does it work?” The second question is, “Does it do harm?” No matter how effective a therapy is, if it harms the patient in the process, it has little value. Doctoral student Robert Skolik and Associate Professor Michael Menze, Ph.D., in the Department of […]
PARIS (Reuters) – Valneva on Tuesday reported positive results for its COVID-19 vaccine in early stage clinical trials and said it planned to launch a Phase Three trial this month. The French drugmaker, whose shot uses the technology behind its licensed Japanese encephalitis vaccine, tested its vaccine in 153 adults with three dose levels based […]
New research from the UVA Cancer Center could rescue once-promising immunotherapies for treating solid cancer tumors, such as ovarian, colon and triple-negative breast cancer, that ultimately failed in human clinical trials. The research from UVA’s Jogender Tushir-Singh explains why antibody approaches effectively killed cancer tumors in lab tests, but proved ineffective in people. He found […]
In a comprehensive analysis of human gene activation data, researchers from the Centenary Institute have discovered that the dipeptidyl peptidase-4 (DPP4) gene family is strongly implicated in the development of human hepatocellular carcinoma (HCC), the most common type of primary liver cancer. Reported in the journal Cancers, the research suggests that the DPP4 gene family […]
Microdosing has become something of a wellness trend in recent years, gathering traction in Australia and overseas. The practice involves taking a low dose of a psychedelic drug to enhance performance, or reduce stress and anxiety. While the anecdotal accounts are compelling, significant questions remain around how microdosing works, and how much of the reported […]
Type I diabetes mellitus (T1D) is an autoimmune disorder leading to permanent loss of insulin-producing beta-cells in the pancreas. In a new study, researchers from the University of Tokyo developed a novel device for the long-term transplantation of iPSC-derived human pancreatic beta-cells. T1D develops when autoimmune antibodies destroy pancreatic beta-cells that are responsible for the […]
(HealthDay)—A mobile robotic system is perceived to be acceptable for use in multiple health tasks, and its use for triage interview is satisfactory for patients, according to a study published online March 4 in JAMA Network Open. Peter R. Chai, M.D., from Brigham and Women’s Hospital in Boston, and colleagues examined the acceptability and feasibility […]
An abdominal aortic aneurysm (AAA) is a bulging of the aorta, the body’s main blood vessel, which runs from the heart down through the chest and stomach. Prevalence of AAA in the population is high, up to nearly 13% depending on age group, particularly for men aged 65 and over. An AAA can get bigger […]
An aggressive type of brain cancer, glioblastoma has no cure. Patients survive an average of 15 months after diagnosis, with fewer than 10% of patients surviving longer than five years. While researchers are investigating potential new therapies via ongoing clinical trials, a new study from Washington University in St. Louis suggests that a minor adjustment […]
(HealthDay)—Adult-onset inflammatory bowel disease (IBD) is associated with an increased risk for psychiatric disorders and suicide attempts, according to a study published online Feb. 26 in the Journal of Crohn’s and Colitis. Jonas F. Ludvigsson, M.D., from the Karolinska Institutet in Solna, Sweden, and colleagues assessed the risk for psychiatric morbidity and suicide in adult-onset […]
