Cholesterol drives Alzheimer’s plaque formation, study finds

Cholesterol manufactured in the brain appears to play a key role in the development of Alzheimer’s disease, new research indicates. Scientists from the University of Virginia School of Medicine and their collaborators found that cholesterol produced by cells called astrocytes is required for controlling the production of amyloid beta, a sticky protein that builds up […]

Genome sequencing shows coronavirus variation drives pandemic surges

Genome sequencing of thousands of SARS-CoV-2 samples shows that surges of COVID-19 cases are driven by the appearance of new coronavirus variants, according to new research from the School of Veterinary Medicine at the University of California, Davis published April 1 in Scientific Reports. “As variants emerge, you’re going to get new outbreaks,” said Bart […]

Chatter between cell populations drives progression of gastrointestinal tumors

Gastrointestinal stromal tumors (GISTs) are a subytpe of cancers known as sarcomas. GIST is the most common type of sarcoma with approximately 5,000 to 6,000 new patient cases annually in the United States. GIST cannot be cured by drugs alone, and targeted therapies are only modestly effective, with a high rate of drug resistance. In […]

‘Genetic rewiring’ drives cancer’s drug resistance

A tiny molecule of RNA—known as ‘micro RNA’ – plays a key role in ‘rewiring’ cancer cells so they can resist the effects of chemotherapy, a new study reveals. The discovery opens up the possibility of creating new cancer drugs that target this micro RNA molecule, rather than more conventional treatments that block the action […]