Design of peptide vaccine for SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an unprecedented global pandemic challenging public health and leading to a dramatic loss of human lives worldwide. Therefore, it is crucial to understand which SARS-CoV-2-specific epitopes can induce a T cell response and offer protection to a broad population to design a vaccine against the novel […]

CXCR6/CXCL16 axis has significant role in the immuno-pathogenesis of severe COVID-19

Scientists are working to contain the current coronavirus disease 2019 (COVID-19) pandemic, caused by the rapid outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). They believe that understanding various aspects of the virus at its genomic and molecular level is extremely important for developing effective COVID-19 vaccines and therapeutics. A better comprehension of SARS-CoV-2 […]

Study reveals why SARS-CoV-2 is more infectious than SARS-CoV-1

Coronaviruses such as the severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are enveloped positive-sense RNA viruses that are a huge threat to public health globally. They can be transmitted from animals to humans and can cause many diseases ranging from the common cold to severe respiratory illnesses. Study: The supramolecular organization of SARS-CoV and […]

Three US COVID-19 vaccines provide substantial protection against hospitalization

The onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an intensive and high-speed consolidation and further development of vaccine technology, leading to the rollout of vaccines against the virus throughout the developed world. Study: Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & […]

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

The ongoing coronavirus disease 2019 (COVID-19) pandemic, which is brought about by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a serious threat to human health worldwide. Previous research has indicated higher rates of adverse outcomes in pregnant women who are infected with SARS-CoV-2. Recently, a new study published on the pre-print server bioRxiv* […]

Inhibition of SARS-CoV-2 replication in vitro by Losartan

The coronavirus disease 19 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already claimed more than 4.1 million lives worldwide. SARS-CoV-2 is a single-stranded positive-sense RNA virus belonging to the Coronaviridae family. Other members of this family include the Middle East Respiratory Syndrome (MERS) and the severe acute respiratory […]

Prior SARS-CoV-2 infection enhances Johnson and Johnson Ad26.COV2.S vaccine immunogenicity

A new study reports that the single-dose Johnson and Johnson Ad26.COV2.S vaccine against coronavirus disease 2019 (COVID-19) shows enhanced efficacy when administered to individuals with pre-existing antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen. This finding becomes more important when it is supplemented by the observation that the vaccine is able to […]

Next-generation COVID-19 vaccine provides robust immunity against SARS-CoV-2 in mice

Researchers in Canada have developed an adenoviral vector-based vaccine against coronavirus disease 2019 (COVID-19) that induced robust immune protection against the ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice. The potential next-generation vaccine candidate also induced robust immunity against the UK B.1.1.7 (alpha) and South African B.1.315 (beta) variants of concern […]

Study associates feelings of discrimination and low status with long COVID-19 symptoms

Following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many patients have reported long-standing symptomatology even after a reasonable period of convalescence. This has been dubbed long COVID and has been noted to occur in as many as 80% of patients at up to four months from the onset of acute symptoms. A […]