A study presented today at the IASLC 2021 World Conference on Lung Cancer suggests how oncology practices in the United States changed after 2018, when durvalumab became available for patients with unresectable Stage III non-small cell lung cancer. In 2018, PACIFIC trial results on durvalumab were published and the U.S. Food and Drug Administration approved […]
Activated mast cell disorders potentially linked to SARS-CoV-2 immunity
A rare set of immune diseases called clonal mast cell activation disorders (cMCADs) may be associated with strong immunity to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the pathogen responsible for the coronavirus disease 2019 (COVID-19). An intriguing new study published on the preprint server bioRxiv* reports a year-long study in patients […]
RNA released from damaged cells acts as signal to initiate repair after injury
New research from the Australian Regenerative Medicine Institute (ARMI) at Monash University has identified novel cell types and RNA signals that may assist with brain and spinal cord repair. Tissues and organs have different capacities to regenerate after injury or disease. Identifying cell types and signals that can promote repair is particularly important for organs […]
New cell phone and smart watch models can interfere with pacemakers and defibrillators
After reports of smart phone and watch interference with implanted medical devices, investigators affiliated with the Center for Devices and Radiological Health (CDRH) at the US Food and Drug Administration conducted a study that supports the FDA recommendation that patients keep any consumer electronic devices that may create magnetic interference, including cell phones and smart […]
Study discovers lagging chromosomes as one of the major causes of infertility
Why do women over 35 have more difficulty getting pregnant? After discovering one of the causes of age-related female infertility, researchers at the University of Montreal Hospital Research Centre (CRCHUM) suggest that it will be possible in the future to improve the quality of the eggs of older patients by intervening on the cell cycle […]
New study reveals unique immune responses to SARS-CoV-2, Ebola and respiratory syncytial virus using B cell repertoire analysis
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, the subsequent pandemic, and the continuous emergence of novel variants continues to make coronavirus disease 2019 (COVID-19) a matter of global public health concern. There is an imminent need to understand how the human body responds to novel infections and this has been […]
Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias
Too many "exhausted" T cells left in the wake of aggressive chemotherapy regimens for patients with advanced chronic lymphocytic leukemia (CLL) make it more challenging for chimeric antigen receptor (CAR) T cell therapy to do its job. Now, a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania shows […]
Study examines the role of programmed cell death ligands in skin immune responses
T cells are a crucial part of the human adaptive immune system. In response to a foreign invader in the body, various subsets of T cells are responsible for several functions that include killing infected cells and secreting signaling molecules called cytokines that tell other immune cells where to go and what to do. Different […]
Revealing the secrets of cell competition
Cellular competition is a crucial quality control process that ensures that the development of an organism relies on healthy cells. Researchers revealed the secrets underlying cell competition and what features can pre-determine whether a cell will survive or not. Defects in energy production are critical in making cells vulnerable to elimination. The study was led […]
Natural compound 'pheophorbide a' demonstrates robust antiviral activity against SARS-CoV-2 in vitro
A team of scientists from France has recently demonstrated photosensitive antiviral activity of the natural compound pheophorbide a (Pba) against a broad range of enveloped viruses, including coronaviruses. The compound has been found to inhibit the entry and reduced the replication of highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle […]