The inhalation of carbon dioxide (CO2) by mice a few hours after they formed a new fearful memory makes that memory stronger, so that the mice show more distress when they are prompted to 'retrieve' (ie, recall) it. That is the conclusion of a recent in Frontiers in Behavioral Neuroscience by neuroscientists from the University […]
Brain beta rhythm predicts early and robust response to deep brain stimulation (DBS) for severe depression in new findings that could help optimize and personalize DBS treatment protocols, early research suggests. In a small study, investigators found brief stimulation at the time of implantation of DBS leads induced a rapid and consistent decrease in beta […]
It remains a central challenge in psychiatry to reliably judge whether a patient will respond to treatment. In a new study published in the journal Biological Psychiatry, researchers from Karolinska Institutet in Sweden and the Max Planck Institute for Human Development in Germany show that moment-to-moment fluctuations in brain activity can reliably predict whether patients […]
The way a person's brain responds to stress following a traumatic event, such as a car accident, may help to predict their long-term mental health outcomes, according to research supported by the National Institute of Mental Health (NIMH), part of the National Institutes of Health. The research, published in the American Journal of Psychiatry, is […]
In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver antibody therapy to breast cancer that has metastasized to the brain. In this Phase I clinical trial for Her2-positive breast cancer patients, the Sunnybrook team captured images […]
As we interact with the world, we are constantly presented with information that is unreliable or incomplete—from jumbled voices in a crowded room to solicitous strangers with unknown motivations. Fortunately, our brains are well equipped to evaluate the quality of the evidence we use to make decisions, usually allowing us to act deliberately, without jumping […]
The study, which appears in the Oct. 4, 2021, issue of Nature Medicine, represents a landmark success in the years-long effort to apply advances in neuroscience to the treatment of psychiatric disorders. This study points the way to a new paradigm that is desperately needed in psychiatry. We've developed a precision-medicine approach that has successfully […]
UT Southwestern stem cell scientists find that stringent lineage tracing is crucial for studies of nerve cell regeneration. Their results, which are published in Cell, show that this tracing is far from routine in the field and suggest that earlier studies reporting "striking" regeneration results must be reexamined. Lineage tracing, which is a fundamental approach […]
Zeroing in on specific brain regions when studying drug and alcohol abuse simplifies research but may leave out important insights. In fact, the landscape of the entire brain reorganizes during withdrawal, potentially hindering communication between regions, according to new research in mice published in eNeuro. Kimbrough et al. administered psychostimulant drugs to mice (cocaine, methamphetamine, […]
Americans are living longer than ever before, but cognitive decline threatens the quality of those last golden years. Now, new evidence suggests that where older adults live may help protect against dementia and Alzheimer’s disease. A trio of University of Michigan studies shows that urban and suburban neighborhoods that provide opportunities for socialization, physical activity […]
