A new monoclonal antibody therapy shows promise in offering an alternative treatment for patients suffering from moderate-to-severe asthma. Research led by Michael E. Wechsler, MD, MMSc, director of the National Jewish Health Cohen Family Asthma Institute, found that itepekimab was safe and effective in a phase 2 trial published online today in the New England […]
The coronavirus disease 2019 (COVID-19) pandemic has resulted in approximately five million deaths over less than two years since it was originally declared a pandemic on March 11, 2020. Study: Modeling Brings Additional Insights into The Kinetics Of SARS-Cov-2 Neutralizing Antibody. Image Credit: LuXiFeR Bowlo / Shutterstock.com Background The transmission of the severe acute respiratory […]
In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver antibody therapy to breast cancer that has metastasized to the brain. In this Phase I clinical trial for Her2-positive breast cancer patients, the Sunnybrook team captured images […]
The number of Covid cases in the UK has risen 12% this week, but while some people may be hospitalized, others will suffer little more than a loss of smell. London Medical Laboratory says new research is now revealing everyone’s immune system is as unique as their fingerprint. Dr Quinton Fivelman PhD, Chief Scientific Officer […]
The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which has expanded its focus to include evaluating outpatient treatment for COVID-19, today announced positive data for the monoclonal antibody combination therapy BRII-196/BRII-198 from the ACTIV-2 study of Outpatient Monoclonal Antibodies and Other Therapies. In an interim analysis of the phase 3 evaluation […]
The virus that causes COVID-19 today is not the same as the one that first sickened people way back in December 2019. Many of the variants circulating now are partially resistant to some of the antibody-based therapeutics that were developed based on the original virus. As the pandemic continues, more variants inevitably will arise, and […]
Total antibody levels appear to start declining from as early as six weeks after complete vaccination and can reduce by more than 50% over 10 weeks, according to new data from UCL’s Virus Watch study. These findings were consistent across all groups of people regardless of age, chronic illnesses or sex. The findings, published as […]
As a result of the ongoing pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease, the coronavirus disease 2019 (COVID-19), the global public health at risk has never been more dire. As a result of SARS-CoV-2 infection, antibodies are produced against a range of viral antigens, including the spike and […]
A new preprint study posted to the medRxiv* server shows an AstraZeneca’s ChAdOx1-nCov-19 and Pfizer/BioNTech BNT162b2 COVID-19 vaccine combination is immunologically superior to two AstraZeneca ChAdOx1-nCov-19 doses. Led by German researchers, the study shows that having the first dose with AstraZeneca’s ChAdOx1 and the second with Pfizer/BioNTech BNT162b2 elicits significantly higher anti-spike titers and more […]
Identifying markers that indicate severe COVID-19 disease trajectories could lead to early medical interventions and help reduce morbidity and mortality. In a new study posted to the bioRxiv* preprint server, a prospective cohort of patients with COVID-19 exhibited distinct features of the IgG fragment antigen-binding (Fab) and fragment crystallizable (Fc) domains, predicting two distinct disease […]
