Dementia: Expert discusses the signs and symptoms Dementia is a general term for a cluster of symptoms associated with brain decline. Alzheimer’s disease is the most common type of dementia in the UK. Memory loss and lapses in judgement are some of the early signs of Alzheimer’s. There is currently no cure for Alzheimer’s but […]
A University of Ottawa study has found a specific Alzheimer’s treatment is effective in male and not female mice, providing a window into the biology of the disease and the effectiveness of targeted treatments. The paper, ‘AB oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner,’ published in Science Signaling […]
A new study on Alzheimer’s disease by Scripps Research scientists has revealed a previously unknown biochemical cascade in the brain that leads to the destruction of synapses, the connections between nerve cells that are responsible for memory and cognition. The findings present a fresh angle for discovering drugs that treat Alzheimer’s disease, which affects roughly […]
Researchers at the University of Gothenburg in Sweden, together with their colleagues at the Barcelona Beta Research Centre in Spain, the University Medical Centre in Ljubljana, Slovenia, and the University of Paris, have found new forms of tau protein that become abnormal in the very early stages of Alzheimer’s disease before cognitive problems develop. The […]
Government health advisers sharply criticized a closely watched Alzheimer’s drug on Friday, concluding there wasn’t enough evidence that the experimental drug slowed the brain-destroying disease. The panel of outside experts for the Food and Drug Administration agreed that a pivotal study in patients failed to show “strong evidence” that the drug worked. The experts warned […]
Researchers at the Hong Kong University of Science and Technology (HKUST) have identified new therapeutic targets for Alzheimer’s disease (AD) by studying the patients’ brain with a newly-developed methodology. This novel approach also enables researchers to measure the effects of potential drugs on AD patients, opening new directions for AD research and drug development. Although […]
Our immune system’s capacity to mount a well-regulated defense against foreign substances, including toxins, weakens with age and makes vaccines less effective in people over age 65. At the same time, research has shown that immunotherapy targeting neurotoxic forms of the peptide amyloid beta (oligomeric Aβ) may halt the progression of Alzheimer’s disease, the most […]
Researchers at the Universitat Autònoma de Barcelona (UAB) have conducted a study which allows estimating the effects of isolation in the current pandemic scenarios in elderly patients with dementia. The findings could serve as a guide to the rethinking of these conditions after the COVID-19 crisis. The study was published in a special edition of […]
Over one hundred years since psychiatrist Alois Alzheimer described the hallmarks of the disease that bears his name, significant gaps in our understanding of how and why the disease develops mean that we still do not have effective treatments. Alzheimer identified deposits of protein that had accumulated in the brain of a patient who died […]
Researchers at the University of Alabama at Birmingham are on the track of a gene that might play a role in the development of Alzheimer’s disease. The research team is studying a gene called BIN1, which was first linked to Alzheimer’s disease in 2009. In a paper recently published online in eLife, the team shows […]
