Scientists have developed a ‘genotype-specific digital-twin’ strategy, Geno-DT, to create a virtual replica of a patient’s heart, providing crucial insights into cardiac health for the diagnosis and treatment of arrhythmogenic right ventricular cardiomyopathy (ARVC). The research, published today as an eLife Reviewed Preprint, is described by the editors as an important study in the field […]

When brain cells, or neurons, are putting out processes to connect with other neurons, how do they tell the difference between their own processes and those of other neurons? One important part of this puzzle involves a molecule called clustered protocadherin (Pcdh). In a recent publication in iScience, researchers from SANKEN (The Institute of Scientific […]

Pregnant patients who received some of their prenatal care during the COVID-19 pandemic in a combination of virtual and in-office visits—known as multimodal prenatal care—had similar health outcomes as those who were seen mostly in person before the pandemic, according to a large new study of more than 151,000 births from the Kaiser Permanente Division […]

New research suggests that inflammation in the meninges, the brain’s protective barrier, may extend into the grey matter and contribute to the development of progressive multiple sclerosis (MS). Researchers used innovative techniques to demonstrate a gradient of immune genes and markers of inflammation extending from the meninges to the adjacent brain tissue in mice. While […]

Patients with risk factors for dementia, such as diabetes and hypertension, experienced a 48% slowing of cognitive decline after wearing a hearing aid for 3 years, results of the first randomized trial of its kind show. Results of the ACHIEVE study add to growing evidence that addressing hearing impairment may be a critically important global […]

Picolinic acid, a natural compound produced by mammalian cells, can block several disease-causing viruses such as SARS-CoV-2 and influenza A viruses, according to a new study by researchers at the Indian Institute of Science (IISc) and collaborators. Published in Cell Reports Medicine, the study describes the compound’s remarkable ability to disrupt the entry of enveloped […]

A recent review published in Frontiers in Immunology introduces the concept of immunodiagnosis (ID), outlines its features, and explores the potential of artificial intelligence (AI) in constructing ID systems for precise tumor immunotherapy. Study: Immunodiagnosis — the promise of personalized immunotherapy. Image Credit: Juan Gaertner / Shutterstock.com Background The immune system is crucial for maintaining health, and […]

Doctors initially thought a man who drunk 10 litres of water a day had diabetes. However, the reality was much worse for Jonathan Plummer, 41, as it turned out he actually had a brain tumour. Appointments with his GP and a kidney specialist initially resulted in inconclusive test results. READ MORE: Musician, 20, fighting rare […]

Reviewers’ Notes Monkeypox (mpox) is a zoonotic disease caused by the mpox virus (MPXV) that has been primarily limited to Central and West African nations since its discovery. The recent spread of the West African lineage of MPXV in historically unaffected countries has raised concerns for global public health. Despite a significant decrease in global […]

Magnetic resonance imaging (MRI) machines can clearly view non-bony parts of the body—soft tissue such as the brain, muscles and ligaments—as well as detect tumors, making it possible to diagnose many diseases and other conditions. However, the powerful magnets in conventional MRI machines make them expensive and bulky, confining them mainly to hospitals and other […]