Better nurse work environments associated with improved stroke outcomes

Stroke remains a leading cause of death worldwide and one of the most common reasons for disability. While a wide variety of factors influence stroke outcomes, data show that avoiding readmissions and long lengths of stay among ischemic stroke patients has benefits for patients and health care systems alike. Although reduced readmission rates among various […]

FDA Targets Cancer Indications That Fail to Prove Benefit

US regulators are stepping up scrutiny of cancer indications that were granted an accelerated approval on the basis of surrogate endpoints but that have failed to show clinical or survival benefits on more extensive testing. At issue are a number of cancer indications for immunotherapies. Four have already been withdrawn (voluntarily by the manufacturer), and […]

Falsely-Accused MD: Charged, Cleared — Now Works in Auto Repair

It was a cloudy October morning, and Joseph E. Oesterling, MD, was in the exam room of his Saginaw, Michigan urology practice preparing for a procedure. Suddenly, the door burst open, and a federal agent charged into the exam room unannounced, frightening Oesterling and the patient.    Bewildered, Oesterling peered outside the room to see […]

Children's National jumps short-term telehealth hurdles while focused on long-term transformation

Children’s National Hospital in Washington was in the midst of an enterprise digital-transformation initiative before the COVID-19 pandemic struck in early 2020. THE PROBLEM The organization was transitioning telehealth platforms pre-COVID-19, and was using Zoom as an interim solution. Telehealth reimbursement realities at that time constrained a compelling business case for significant capital investment in a new […]

Scientists shrink pancreatic tumors by starving their cellular ‘neighbors’

Scientists at Sanford Burnham Prebys Medical Discovery Institute demonstrated for the first time that blocking ‘cell drinking,’ or macropinocytosis, in the thick tissue surrounding a pancreatic tumor slowed tumor growth—providing more evidence that macropinocytosis is a driver of pancreatic cancer growth and is an important therapeutic target. The study was published in Cancer Discovery, a […]

Researchers provide complete clinical landscape for gene linked to epilepsy and autism

Researchers from Children’s Hospital of Philadelphia (CHOP) affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have compiled a complete genetic and clinical analysis of more than 400 individuals with SCN2A-related disorder, which has been linked to a variety of neurodevelopmental disorders, including epilepsy and autism. By linking clinical features to genetic abnormalities in a standardized […]

Canada’s Medicago Begins Late-Stage Study of COVID-19 Vaccine

(Reuters) – Canadian drug developer Medicago said on Tuesday it had started a late-stage study of its experimental COVID-19 vaccine combined with an adjuvant from GlaxoSmithKline. The study plans to eventually enroll 30,000 participants and initially focus on healthy adults, followed by adults over the age of 65 and those with co-morbidities. Medicago, which has […]